Study On The Protective Effects And Mechanisms Of Potassium 2-(1-Hydroxypentyl)-benzoate (dl-PHPB) In Cerebral Ischemia

Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB), derivated from 3-n-butylphthalide (dl-NBP), is a newly synthesized compound which is under development as a therapeutic drug for cerebral ischemia.In our previous research, it was found that dl-PHPB could transform to dl-NBP fast by pH disposal or enzyme esterification (esterase) when given to rat orally or intravenously and it also has the exactly protective effects on cerebral ischemia.As reported, dl-NBP is a primary naphtha component from seeds of Apium graveolens Linn. The phase 3 clinic trail of dl-NBP completed in 2002 and has been used for treatment of ischemic stroke in clinic. Many basic and clinic studies have proved that dl-NBP is a potentially beneficial and promising drug for treatment of stroke with multiple actions which affect different pathophysiological processes, while the research of dl-PHPB just began. Compared with dl-NBP, physical and chemical properties of dl-PHPB have been improved, and the applications also expanded.My dissertation mainly focused on the studies of the protective effects of dl-PHPB on cerebral ischemia. And then, I further studied the potential mechanisms of dl-PHPB against mitochondrial dysfunction induced by ischemic brain injury, especially on protective mechanisms relevant to mitochondrial respiration and energy metabolism, and influences on apoptosis in relation to mitochondrial pathway.