Effect Of Antioxidant Seleno-organic Glutathione Peroxidase Mimic PZ51 On Vasculature, Cerebral Cortex And Heart Of Stroke-prone Spontaneously Hypertensive Rats

Background Stroke is the major public health problem with high mortality and disability, and is a heavy burder to the society and involved family. There is no specific and effective treatment to stroke and about 75% of patients with stroke are left disable to different levels even if they were treated in time. In that case, it is of paramount significance to explore the preventive mehtod against stroke. The underlying mechanism of stroke is cerebrovascular impairment to which endotheliul injury is an initiating factor. Hypertension is the most important risk factor of stroke. In hypertensive status, the balance between the oxidative and antioxidative system is broken. The level of intrinsic antioxidants is very low in the blood and cerebral cortex, but the level of reactive oxygen species are high. The high level of reactive oxygen species plays an important role in the impairment of cerebrovascular system and cerebral cortex.PZ51 is a newly developed seleno-glutathione peroxidase mimic with antioxidant property. The purpose of the present experiment is to investigate whether long-term administration of PZ51 would have a protective effect on the endothelial cells, vascular remodeling and cortical neurons in stroke-prone spontaneously hypertensive rats (SHRsp), and, if so, the possible mechanisms of this effect. We hope that we can provide basic data to the prevention of human stroke. In this experiment, we also explore the effect of PZ51 on another important hypertension-related target organ, the heart of SHRsp.Three aspects are included in this experiment.