| Resveratrol(trans-3,4',5-trihydroxystilbene) is a phytochemical which was synthesized in various plant species such as grapes, Veratrum and Polygonum cuspidatum. Resveratrol has been suggested in many studies to be an antioxidant, anti-inflammatory and antiplatelet agent, as well as a modulator of lipid and lipoprotein metabolism. The aim of the present study was to assess the cancer chemopreventive effects of resveratrol and elucidate the mechanism underlying these activities. Main results could be summarized as follows.1. Effects of resveratrol on cancer chemopreventionBalb/3T3 fibroblasts were chemically transformed by 3-MCA and TPA. By using this two-stage chemical transformation model in vitro, resveratrol was found to prevent transformation of Balb/3T3 fibroblasts at relatively lower concentration. The average number of transformed foci decreased dramatically when 1.25 μM, 2.5μM, 5 μM resveratrol were incubated in the medium by 17.2%,23.3%, 51.0% respectively. We investigated the chemopreventive potential of resveratrol by testing it against mammary carcinogenesis induced by DMBA in female Sprague-Dawley rats. Administration of resveratrol had no evident effect on tumor incidence, but produced reductions in tumor burden and tumor volume compared with control group. The number of DMBA-induced tumors per rat was reduced from 2.44 ±1.90 in control group to 1.29±1.36 in the rats treated with lOOmg/kg resveratrol (p<0.05). There were no significant differences in levels of estradiol and progesterone between...
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