| Nonalcoholic fatty liver disease (NAFLD) is now recognized as the most common type of liver diseases and might lead to important public health problems. This disease, with an unclear natural history, can be severe and is characterized by a wide spectrum of pathological lesions. These lesions closely resemble those induced by alcohol, but were observed in patients without excessive alcohol consumption. Steatosis alone does not appear to be progressive, while nonalcoholic steatohepatitis (NASH) does, since the latter often progresses to more severe stages of liver injury such as fibrosis, cirrhosis and even hepatocellular carcinoma. Thusfar, no therapy for NASH has clearly been proven effective. Animal models of steatohepatitis, obesity, insulin resistance and dyslipidemia, are valuable for studying the pathogenesis and treatment of NASH as well as its relationship to metabolic syndrome. However, for a long time, studies have failed to clearly define the molecular and physiological changes that mediate the presumed transition from hepatic steatosis to steatohepatitis due to the lack of animal models carrying key features of human NASH.Baopizhang (also called Laoying tea) is the leaf of Litsea Coreana level which distributes in Sichuan, Guizhou and south of Anhui province in China. Boapizhang had been traditionally used in China as a health protective tea for many years. Previously...
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