The Study Of Novel Chiral Selector Based On Chelate-inclusion Duel Interaction By CE

Chiral recognition has attracted more and more attention in the pharmaceutical, medical, and biological fields. For example, unwanted side effects or even toxic effects can occur with the second enantiomer in several cases. Even if the side effects are not drastic , the inactive enantiomer has to be metabolized and represents an unnecessary burden for the organism. Therefore, The development of methods for enantiomeric separation is very important for controlling asymmetrical synthesis, enantiomeric purity check and pharmacodynamic studies.Cyclodextrins(CDs) have been become an object of interest in many fields due to their ability to form inclusion complexes and to show regiospecificity and stereospecificity with respect to the analytes. The introduction of functional group could greatly improve the CDs ability to form inclusion complexes and catalytic properties. Moreover, for more sophisticated molecular recognition, double or multiple recognition systems have been obtained by means of the metal complexes of functionalized cyclodextrins where the additivity of cavity and metal-ligand interaction has been demonstrated. The purpose of this work is to try to explore the potentiality of the metal complexes based on amino-substituted cyclodextrins as a new class of selector using capillary electrophoresis, and develop a simple, fast and sensitive chiral analysis method. The dissertation is divided into the following sections:In the introductory chapter, the application of the capillary electrophoresis in chiral analysis and the main chiral selector were reviewed. Subsequently, the research proposal of this dessertation was presented.In chapter two, a series of 6-amino-mono-substituted cyclodextrins were...