The Influence Of Intergrin αvβ3 On Bone Marrow Micrometastasis In Breast Cancer

Integrin is heterodimers which formed by subunit a (120-185KD) and β(90-110KD). Integrin has two major functions, transferring information between interior and exterior of cell and connecting cell and extracellular matrix. Metastasis is the main death cause of breast cancer. For the past few years, researchs in the metastasis mechanism of breast cancer reveal the important function of integrin-mediated signal in tumor formation, growth, invasion and metastasis.In this study, the expression of receptor αvβ3 in breast cancer lines, the impact on the ability of tumor cells in adhesion and migration, the function of modulating transmembrane signal of tumor cells and the therapy examination on bone marrow micrometastasis by antibody of receptor αvβ3 in nude mice model were studied to find the relationship between the αvβ3 expression and migration of breast cancer cells and to seek the possibility of treating bone marrow micrometastasis by using the antibody of receptor αvβ3 in breast cancer.PART ONE The impact of integrin αvβ3 on cell adhesion and migration in breast cancer lines...