| Diabetic Mellitus and Obesity have been epidemic in western countries, and it has been one of the most common great diseases which affect people's life and health in China. Complications, Such as insulin resistance and hyperglycaemia, hypertention hyperlipemia have exerted heavy burden on our society. Therefore, it is important to explore the molecular mechanism and screen the drug target to control Diabetic Mellitus and Obesity as well as their complications.11β-hydroxysteroid dehydrogenase type 1 is a microsome enzyme located in various tissuses. It interconverts inactive cortisone and active ortisol, regulating the level of cortisol. Glucocorticoid as a pre-receptor regulator promote adipocyte differentiation11β-HSD1 knockout mice have low intracellular glucocorticoid levels, and are protected from obesity, diabetes, and dyslipidemia. Conversely, transgenic overexpression of 11β-HSD1 in white adipose tissue results in mice with elevated intracellular glucocorticoid levels, central obesity, insulin resistance, hypertension, hyperglycemia, and dyslipidemia , which were further performed to explore the potential role of 11β-HSD1 in vitro preadipocyte differentiation and in rats with diet-induced obesity (DIO). Protein expression of 11β-HSD1 in the process of 3T3-L1 cell differentiation and in various tissues of the rats...
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