The Effect Of Jiangu Capsules On Pathology Changes Of Cartilage And Synovia Of Osteoarthritis

Objective: To study epidemiology and pathogenesis of osteoarthritis(OA) in TCM, and to study the effect of Jiangu capsules on pathology of cartilage and synovia of OA on experimental rabbits.Methods: Make the OA models by injecting papain to the knees of experimental rabbits. Select Glucosamine Sulfate Capsules as the control group. Observe the effection of histology of joint cartilage and synovia, and the levels of matrix metalloproteinases(MMP)-1,3, tissue inhibitor sofmatrix metalloproteinases (TIMP) -1, interleukin(IL)-1βin cartilage and synovia.Results: The histology changes of cartilage and synovia were lighter in Jiangu capsules group than that in model group (p<0.01). The levels of MMP-1,MMP-3, IL-1βin cartilage and synovia were decrease and level of TIMP-1 was increase. It showed significant different in Jiangu capsule group and the model group( p<0.01 or p<0.05).The level of IL-1βshowed significant different (p<0.05) and others showed insignificant different (p>0.05) in Jiangu capsules group and the control group.Conclusion: Jiangu capsules can decrease the degeneration of joint cartilage and synovia and the synovitis. Its mechanism is related to reduce the expression of IL-1βand to adjust the levels of MMP-1,MMP-3 and TIMP-1.