| Occupational lead poisoning was the most popular occupational poisoning in China over years (blood lead concentration was above 500μg/L). Kidney was the most sensitive target organ of lead second only brain, lead nephrosis harmed kidney delitescencely, and was difficult to discover. Unfortunately, the mechanism of lead nephrosis is not uncovered thoroughly. Studying on the mechanism of lead toxicity to nervous system abroad was found that the damage of lead to nervous system may related to the disorder of LTP resulted by loss of control among lead mediated intracellular signal transduction, such as serine/ threonine kinases pathway et al. Therefor, we supposed there might exist similar mechanism in lead nephrosis, and we hope to provide a new way for diagnosis, prevention and cure of lead nephrosis. In this study we used HK-2, a cell line of human proximal renal tubular endothelial cell, and investigated the lead effect of signal transduction mediated by calcium ion, PKCα, NFkB and IKKβ and apoptosis related proteins bax, bcl-2 and XIAP, and the expression of these peoteins. We even investigated the effect mediated by kalium iodidum on the course above after stained by lead. We tried hard to explain the mechanism of lead nephrosis from this point, and hope to provide a new way to cure this disease. This paper was divided into three parts.
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