The Experimental Study On The Influence Of Willed Movement Therapy On Neural Plasticity Of The Adult Rat Following Focal Ischemia

Stroke is a disorder with high incidence and mortality rates, leaving a large proportion of survivors with significant physiological, cognitive and psychological disabilities. Recently, the excitatory amino acids are linked critically to neurotoxic role in the ischemic stroke by clinicians. In the acute ischemic stroke, it is generally believed that downregulation of GluR2 expression or a larger value of the ratio (GluR1 + GluR3)/GluR2 are possibly associated with greater Ca²⁺ permeability through AMPA channels and are likely to contribute to the delayed neuronal death. Others believed that downregulation of GluR2 expression induces a delayed rise in intracellular Zn²⁺ through AMPA channels and are also likely to contribute to the delayed neuronal death in the acute ischemia stroke. Although the role of the AMPA receptor in the acute ischemic stroke is well established, the mechanisms of the AMPA receptor in the subcute ischemic stroke are less clear.Until Liao initially proposed that silent synapses presented in the neuron cell and the insertion of new AMPA receptors is able to convert silent synapses to active synapses in 1995, the study of the role of the...