Screening And Identification Of The Interacting Proteins Of HBV Post-Transcriptional Regulatory Element

Chronic HBV infection is a global public health problem, particularly in China. According to epidemiology investigation, in China, about 57.63% people are the prevalence of hepatitis B and 10.34% are the surface antigen (HBsAg) carriers. Every year about 300 thousand people died of terminal liver diseases and cancers. One characteristic of HBV spreaded in China is that the anti-virus drugs have little even no functions on virus infection, and the reasons are thought to be as follows:â‘ The cccDNA, used as replication template of HBV, could not be cleaned by drugs;â‘¡HBV mutation;â‘¢human immune tolerance. However, anti-virus treatment is the essential step in curing HBV infection. It is imperative and perspective to develop novel drugs aimed at different targets and mechanisms in order to improve curative effects.The HBV could adjust self replication and host immune function at several component elements such as replication, expression, transcription, post-transcription, et al. And the transcription regulation which has been deemed as the principal stage is the first step. However, as researchers got...