Study On Histone Acetylation Modification Mechanism Of MSCs Differentiating Into Cardiomyocytes

Background:Cellular replacement therapy is an effective treatment for terminally-phase cardiovascular diseases.With the development of using stem cells transplantation to treat heart diseases, mesenchymal stem cells (BMMSCs) become the most fascinating scenes because they are easily to be obtained, proliferated, rarely graft versus host disease and rarely ethic or moral limited. Great success has been gained not only cultivation in vitro but also transplantation in vivo. Up to date, the mechanisms underlying BMMSCs improvement of cardiac function still need more analyzing, especially whether BMMSCs can differentiated into useful cells in host myocardium or not and what is the key regulation factor in MSCs differentiated into cardiomycytes.In eucaryote,nucleosome is the basic unit of chromosome, and it is composed of histone octamer, which is made of H2A, H2B, H3, H4 and DNA that band it. Materials show that the central histone could affect transcription both in vivo and in vitro. The recent research shows that the...