Construction Of Recombinant Helicobacter Pylori Vaccine And Its Immunoprotection Effects And Mechanism Study

Background and objective: Helicobacter pylori (H. pylori) is a major pathogen of chronic active gastritis and peptic ulcer, and plays an important role in the pathogenesis of gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. The current treatment for H pylori infection is based on antibiotics together with a proton pump inhibitor or antacid, which leads to eradication of the bacteria in more than 90% of the cases. However, the eradication treatment has several disadvantages, such as adverse effects of antibiotics, emergence of antibiotic-resistance strains, high cost and poor compliance. So, vaccination has been considered as one of the effective ways to eradicate H. pylori infection all over the world. Nowadays, investigation of H.pylori vaccine is mainly focused on the development of protein vaccines. However, the preparation and purification of protein antigen is laborious, and effective immune responses are induced only at the presentation of mucosal adjuvant. Thus, the development of an effective vaccine against H.pylori has become the hot spot in the world. Massive trials have proved that the recombinant live vector delivery system for heterologous antigens does not require antigen purification, and can not...