Gd-PBCA Nanoparticles As Novel MR Contrast Agents Targeted Reticuloendothelial System: Synthesis And Comparison With SPIO In MR Lymphography

Objective一,To prepare polybutylcyanoacrylate (PBCA) nanoparticles loaded with Gd-DTPA and optimize the preparative conditions.二, Compared to Gd-DTPA, to investigate the effect of Gd-PBCA-NP as MR specific contrast agents targeted imaging for liver in animal experiment and debate the potential value of its clicinal application.三,To further evaluate the effect of Gd-PBCA-NP targeted lymphatic tissue and thevalue of the MR lymphography to differentiate metastatic from benign lymph nodeswas compared between Gd-PBCA-NP and SPIO as specific contrast agents forreticuloendothelial system after interstitial administration of Gd-PBCA-NP and SPIO.Materials and Methods一,Preparation and optimization of Gd-PBCA-NP(一) Determination the preparation technicsGd-PBCA-NP were prepared by anionic emulsion polymerization of monomeric PBCA (V/V) in an aqueous medium containing 0. 1N HCl and fixed quantity of...