Effect Of Shenkangwan On The TGF-β₁/Smad Signaling Pathway In Diabetic Nephropathy

Diabetic nephropathy (DN) is one of the most familiar and refractory vascular complications of diabetes mellitus (DM) in clinic. And it is a leading cause resulting in death among the end-stage renal disease and DM patients. About 40% type 1 and 5-20% type 2 DM patients might run to DN. With the amelioration of modern people' living and change of dietetic structure, the incidence of DM is rising rapidly among the world. And such does the incidence of DN. So how to treat and prevent the DN effectively is becoming a common concerned problem among the international medical researchers.DM might damage the patients' kidney from varies of ways and including all structure of the kidney, which could cause the proliferation and hypertrophy in glomerular cells, thickening of the glomerular basement membrance, ceaseless accumulation of extracellular matrix (ECM) and lead to glomerulosclerosis in the end. Transforming growth factor beta 1 (TGF-β₁ )is a multiple functional cytokine and has a assured effect in the pathogenesis of DN. These include inducing the proliferation and hypertrophy of the cells in the kidney, increasing the synthesizing and secretion of the ECM, decreasing the decomposition of the ECM via increasing the active effect of inhibitors of metalloproteinases and so on. Smad protein is a...