Effects Of AGEs On C-Reactive Protein Production In Human Fetal Hepatocytes

BackgroundCardiovascular diseases (CVD) remain the main cause of morbidity and mortality in patients with chronic kidney disease (CKD). The incidence of atherosclerosis is 10 to 20 times higher in CKD patients than in the general population. Because of the high morbidity and early onset, it is also called "accelerated atherosclerosis". However, the causes of accelerated atherosclerosis in CKD patients remain incompletely understood, In recent year, the "micro-inflammatory state" which is commonly observed in CKD patients attracts great attention. Accumulated data have shown that there are persistent and low-grade inflammatory state in CKD, which presented by increased plasma pro-inflammatory cytokines and acute-phase reactants(C-reactive protein (CRP)). Among them CRP is the most attractive research aspect during recent ten years.CRP is a member of the pentraxin family of proteins, serum CRP levels increase rapidly in the condition of trauma, infection, inflammation and malignant tumour. Abundant clinical evidence demonstrates that elevated C-reactive proteins are associated with higher all-cause mortality and cardiovascular disease mortality among patients with chronic renal failure. And multivariate Cox regression analysis identified age and CRP levels (not other nontraditional risk factors) as the most powerful predictors of cardiovascular mortality in hemodialysis patients.The cause of "microinflammatory state" and elevated levels of CRP is incompletely known. There are several theories having been established such as...