The Effects Of Apnea On Cochlear Function

ObjectiveTo investigate the effects of apnea on cochlear function, the changes of co-chlear blood flow (CBF) and endocochlear potential (EP) were detected when body suffered apnea and artificial breathing recovered. The effects of obstructive sleep apnea - hypopnea syndrome ( OSAHS) on otoacoustic emissions ( OAE) were also studied in this study.Methods30 patients (60 ears) of OSAHS diagnosed by polysomnography ( PSG) were selected as experiment group; 20 normal persons (40 ears) without sleep apnea were selected as control group. Both groups had no system and local diseases to induce auditory function disturbance. Pure tone auditory threshold, a-coustic immitance test, distortion - product otoacoustic emissions ( DPOAE) , and transient evoked otoacoustic emissions ( TEOAE) were all detected in the two groups.69 guinea pigs of 4 weeks age with normal Preyer's reflex were used in this animal study. All guinea pigs were general anesthetized, trachea incised, and muscles relaxed. Artificial respiration was used, the respiratory rate was set at 70 breaths/min, with 1.5ml/breath of tidal volume. The mean blood press ( mBP) was monitored and the rectum temperature is maintained at about 38℃. 35 guinea pigs were divided into 5 groups, they suffered asphyxia for 1 to 5 minutes separately. CBF and skin blood flow (SBF) were measured by laser -...