Lymphoblastic Lymphoma And Acute Lymphoblastic Leukemia: A Clinicopathologic And Immunophenotypic Study Of 153 Chinese Patients And The Expressions Of HOX11L2 And HOX11 Genes In T-Lymphoblastic Lymphoma/Leukemia

Background and objectivesPrecursor T- and B- lymphoblastic lymphoma/leukemia (T/B-LBL/ALL) is a highly aggressive lymphoid malignancy. T-LBL comprises approximately 85-90% of all lymphoblastic lymphoma/leukemia. The patients typically with mediastinal mass and lymphadenopathy are almost children and adolescent males. B-ALL/LBL is relatively uncommon and the patients are more frequently with leukemia than lymphoma. In China there are few large series studies of lymphoblastic lymphoma/leukemia based on clinicopathologic and immunophenotyping study.Chromosomal aberrations are present in 60-90% cases in ALL. There are several important cytogenetic features with prognostic significance. For example, the transcriptional activations of genes coding transcriptional factors HOX 11L2 and HOX 11 play a key role in the pathogenesis of T-ALL. Recently researches show that there are approximately 20% cases of pediatric...