A Research On The Morphologic Basis Of The Paraventricular Nucleus Of Hypothalamus For Neuroimmunomodulation

Accumulating evidence has indicated that the paraventricular nucleus of hypothalamus (PVH) is involved in regulation of immune function. And there is bidirectional communication between the PVH and the immune system via neural and humoral connections. But it has not been reported about the direct neural pathway which connect the PVH and the lymph nodes of the immune system. Peripheral immune signals induces the expression of several signals molecules in the PVH, however, the intracellular signal transduction pathways which activates the PVH is not well understood. In this research the further study is made in an immune irritant rat model which set up by intraperitoneally injected LPS, using saline for LPS control.The present study includes three parts, as follows,1. In order to study the role of the neural pathway which connect the paraventricular nucleus of hypothalamus (PVH) and the lymph nodes , the study in this part employed the pseudorabies virus(PRV,Batha strain) transneuronal tracing technique to investigate the distribution of the neurons controlling the mesenteric lymph nodes in the PVH of the rat, and immunocytochemical methods was used to observe the changes of the c-fos...