Effects Of Transforming Growth Factor-β1 And Decorin On Proliferation And Expression Of HSP47mRNA In Tenon's Fibroblasts

Backgrouds: Glaucoma is a severe blind leading disease .Reducing the intraocular pressure (IOP) is the main therapeutic measure . Glaucoma filtration surgery (GFS)is the most popular strategy applied to reduce the IOP. However, Fibroproliferating and collagen formation resulted from the fibroblasts lead to the obstruction of the created fistula and subconjunctival filtration area. Antifibrotic therapy is the main means to prevent scarring .Antifibrotics, such as 5-fluorouracil and mitomycin C, are widespread clinically applied to increase the success of surgery.Despite the positive effect on the success rate, diffusion into adjacent ocular tissues may result in impairment of other than the targeted cells and in complications of conjunctiva, cornea, sclera, ciliary body and trabecular meshwork. New strategies are being developed, to find a more effective and less complication way to suppress the wound-healing process.Heat shock protein47(HSP47) is a 47-kDa stress protein that is a collagen-specific molecular chaperone residing in the endoplasmic reticulum (ER). HSP47 is closely involved in the folding, assembly, modification and transport of procollagen. HSP47 might be involved in a quanlity control...