Recombinant Adenovirus Induced RNAi Suppress Expression Of Epidermal Growth Factor Receptor (erbB1) In ErbB1-overexpressing Cells And Tumor

Background and Objective: Epidermal growth factor receptor (EGFR or erbB1) is a glycoprotein with a molecular weight of 170 000 with an intrinsic tyrosinespecific protein kinase, which is stimulated upon EGF binding. Activation of EGF receptor tyrosine kinase results in the generation of a number of intracellular signals that culminate in cell proliferation. The known downstream effectors of EGF receptor include PI3-K, RAS-RAF-MAPK signal pathways, and protein kinase C signaling pathways. EGF receptor signaling involves in cell growth, angiogenesis and DNA repair. Deregulated and excessive expression of EGFR, the transmembrane receptor tyrosine kinase , is a feature and/or cause of a wide range of human cancers, especially in epithelium cell originated carcinomas. Blockade of EGF receptor signaling pathway represents a new perspective on the development of novel and selective anticancer therapies. Although considerable progress has been made in the application of EGF receptor —targeted antibodies and...