The Effects Of Orthodontic Force On The Periodontal Tissues After Guide Tissue Regeneration With Emdogain-an Experimental Pilot Study Inbeagle Dogs

With the society development, more and more people with periodontal support tissue lost have the requirement of orthodontic treatment. Periodontal tissue plays a very important role during orthodontic teeth movement and is very close relative to the stability of occlusion after orthodontic treatment. So the orthodontist care more about the relationship between periodontal regeneration and orthodontic tooth movement.More recently, enamel matrix proteins (Emdogain^?)have been introduced to stimulate periodontal regeneration successfully. However, no reports show whether the regenerated periodontal tissue induced by Emdogain might be available for remodeling during orthodontic tooth movement. The present study will be carried out to investigate histological changes of the newly regenerated periodontal tissue induced by Emdogain applied to an experimentally formed alveolar bone defect in beagle dogs. The histological reaction in the regenerated periodontal tissues induced by experimental tooth movement will be examined. Through IHC and ISH, the rules of Cbfa1, OPG and ODF which are key factors involved bone remolding between the periodontal regeneration with EMD and the normal periodontal tissues will be compared. Then it can be provided some preliminary experimental evidence whether the tooth after periodontal regeneration with EMD is suitable to orthodontic tooth movement.