Immune Regulatory Effect Of Bone Marrow Mesenchymal Stem Cells On T Lymphocyte And Parent-Into-F1 Model Of Graft-Versus-Host Disease

Objective Graft-versus-host disease (GVHD) is the major complication of allogeneic haematopoietic stem cell transplantation. In this process, donor T cells recognize alloantigens on host-derived antigen-presenting cells and initiate a cascade that results in target tissue damage. Although standard GVHD prophylaxis regimens are applied in allogeneic haematopoietic stem cell transplantation, steroid refractory GVHD is still a major problem, posing a substantial threat to the patient's life and well-being.Effectors mechanisms of acute GVHD include inflammatory effectors such as TNF-α and IL-1, as well as cellular effectors such as natural killer cells and cytotoxic lymphocytes (CTLs). Inflammatory effectors functions of mononuclear phagocytes are preferentially stimulated by cytokines, such as IL-2, IFN7, that are secreted by activated type 1 T-cell. These effectors functions are inhibited by IL-4 and IL-10, cytokines produced by type 2 T cells. aGVHD is an immunologic reaction of the donor's immune system...