Non-invasive Detection Of Vasodilation In Vivo Compared With Vascular Reactivity Studies In Vitro In The Hypercholesterolemic And Atherosclerotic Rabbit

Background:Hypercholesterolemia(HC) is the main risk for atherosclerosis(AS).Elevated LDL from high serum cholesterol undergoing oxditative modification is the predominant atherogenic lipoprotein.According to current concepts,this oxidized LDL becomes capable of a wide range of toxic effects,leading to endothelial cell/vessel wall dysfunctions which are consistently associated with the development of atherosclerosis in large arteries. One of the first endothelial dysfunctions observed in HC states is an injury of endothelium-dependent dilation(EDD) which is regulated by EDRFs/NOx...