Experimental Study Of Modulating Roles Of TGF-β And HSP70 In RhIL-1β Mediated Inflammatory Lesion Of Condylar Cartilage Of TMJ

Temporomandibular joint (TMJ) is one of the most complicated joints, which belongs to synovial joints. TMJ may suffer from osteoarthrosis (OA), whose pathologic changes is basically the same as other synovial joints.Temporomandibular joint disorder (TMD) occurrs frequently in clinic. Accumulating evidence based on direct visualization of the inner compartments of the TMJ support the existence of inflammatory process associated with structural changes, especially in the internal derangement (ID). Inflammation of the synovial membrane alters synovial fluid viscosity, leading to impairment in the lubrication and the nutrition of the articular cartilage. Activation of enzymes, after the inflammatory process, produces deleterious effects on both the articular cartilage and synovium. These pathological changes are accompanied by synovial proliferation, fibrosis in the synovial membrane, adhesions of the disc with synovium, causing a closed lock and OA in TMJ. Recently, more and more researches have focused on the relation between TMJOA and TMJID. So the researches of the relationship of TMD, TMJID and TMJOA are of great value for us to know their pathogenesis and mechanism, especially in finding new ways in the treatment of them.The purpose of our researches is to investigate the proliferation, differentiation, and apoptosis mediated by the recombinant human interleukin-1β (rhIL-1β)and the modulation of transforming growth factor-beta (TGF- β) and Heat shock protein 70...