Targeting Human Monocytes-macrophages By Bispecific Monoclonal Antibody On Human Hepatocellular Carcinoma

Bispecific monoclonal antibody (BsAb) is constructed by two different kind of molecular of monoclonal antibodies. BsAb can combine with two different epitopes, one combination situs can specifically identify and combine with tumor cells or pathogen, the other can induce the macrophages or monocytes and other immunologically competent cells to kill the tumor cells or pathogen. BsAb combines with those cells in variable region, it can prevents other amount of antibodies from competing in tumor targeting therapy. So the targeting therapy effect of BsAb on tumor has greatly improved than merely monoclonal antibody.Recent studies about activating killer cells by BsAb to combine the antibodies with cells and factors has become one of...