A Study On The Mechanism Of Inflammatory Intradental Hyperalgesia

Intradental pain, especially the spontaneous pain caused by pupitis, is the most common symptom that compels, patients to seek dental therapy. Intradental hyperalgesia is of complicated mechanism, which is not clearly understood.Either of nerve fibers in the pulp of clinical pulpitis or of nerve fibers treated with 5—HT, histamine.the intracelluler Ca²⁺concentrations are significantly higher than that of nerve fibers in normal pulp.While in low Ca²⁺extracellular solution,no significant difference in intracellular Ca²⁺concentration was found between histamine treated and normal groups .The results suggest that the increase of intracellular Ca²⁺, as a result of Ca²⁺influx, play an important role in intradental hyperalgesia.Observation in a variety of central pathways have provided evidence that fos expression can be used as a marker for neuronal activation. Fos has been demonstrated following various forms of noxious stimulation in a distribution that is consistent with the known distribution of nociceptive neurons. In this study,it was found that 1 % carrageenan induced acute pulpitis could give rise to the expression of c—fos in I , II , V laminae, where predominantly nociceptive neurons locate, of trigeminal spinal caudal subnucleus, and the expression could be suppressed by morphine. As a result,...