The Expression Of Vascular Endothelial Growth Factor And Its Role In The Oncogenesis Of Human Gastric Carcinoma

Tumor angiogenesis plays a crucial role for the growth and metastasis of tumor. Anti—angiogenesis opened up a vast range of prospects for tumor growth inhibition. Vascular endothelial growth factor (VEGF) was Originally found in the conditioned medium of guinea pig line 10 tumor cells grown in vitro. VEGF interacts directly with its receptor on endothelial cells to increase microvascular permeability, resulting in extravasation of plasma proteins. In addition, VEGF is a selective mitogen for endothelial cells, and may directly stimulate cell proliferation. Through its action on endothelial cells, many other angiogenic factors can promote the neovascularization of tumor. In short, VEGF has direct effect on the key link to angiogenesis, which is continous endothelial cell proliferation. VEGF has been found over — expressed in many solid tumor, and it has been suggested that targeting at VEGF/VEGFR might afford an approach in the gene therapy of solid humor.To evaluate the role of VEGF/VEGFR in the growth of human gastric cancer, we first studied the expression of VEGF and its receptor KDR in human gastric cancer tissue by immunochemical staining, and we also investigated the expression of VEGF in human gastric cancer cell line SGC —7901 by Western blotting. later, we explored the correlation between the expression of VEGF and...