| ObjectiveTo investigate the clinical result of improving function of theGuiLuBuShen capsule on the quality of the bone in the postpausal osteoporosisthrough the observe of clinical research. Methods to demand the improve effectsof the bone after the result of drug feed. Points of the result by observethe deficiency of kidney-yang, the level of estrogen, bone mineral densityand biochemist sections of blood. Accord to these points we can see the improvefunction of GuiLuBuShen capsule on thee quality of the bone in the PMOP. Wealso observed the association and availability of the pharmacology of ChineseHerbal Medicines. At the same time we proved the relation between kidney andbones. For the theory of "the kidney dominates the bone" of TCM and offerexternal guideline of the methods tocure PMOP that include "tonifying thekidney", "tonifying the kidney and remove blood stasis" and "tonifying thekidney and invigorating the spleen". According to these we can build the indexof clinical application in the PMOP by Chinese compound prescriptions.MethodThe clinical research: 60PMOP patients (ages between 49 to 68 years oldand from 2006-02 to 2007-01) were observed by randomly divided into GuiLuBuShen capsule group and XianLingGuBao capsule group. Samples of the standardtype include:①Clinical appearance match to PMOP;②Bone mineral densityexamination match to the approach points of osteoporosis;③Patients with traitof TCM syndrome differentiation. The exclusion type of patients are:①To breakthe remedy process or who take less medicines for treatment;②Take othermedicines that were not allow in the plain of cure and would effect bonemetabolism;③Patients with diseases that would effect bone metabolism;④According to the lab examinations that could be exclusion by secondary osteoporosis;⑤Patients takes medicine out of rules that would interruptedthe syndrome differentiation methods and effect the exam results or make thedata of observation uncompleted should be exclusion. Method of group dividedwas made by simple random type. We separated 60 patients into 2 groups (treatand control groups); 30 in each group. The methods of observation and thepatients of control group were GuiLuBuShen capsule for treat group took themedicine 2 times per day, each time take 3 capsules. Both groups should takemedicines remedy for 6 months. After 6 months of medicines treatment. Weobserve the points of clinical syndrome of TCM, BMD, E2 and ALP. The standardsof the points of clinical syndrome of TCM were judged by:①TCM new drug newdrug guide book, According to the methods were sume the points of results;②The points of the deficiency of kidney-yang was judged by the questionnairesof the clinical syndrome;③Biochemist indexes include estrogen, ALP and bonemineral density were test before and after 6 months of the 60 patients tomeasured the bone mass and metabolism exam of bone.ResultAfter we compared the points of all the 60 patients of PMOP by treatmentand control groups and made the conclusion of results. The total effectualratio of treatment was 86.67％. Compared with control(total effectual ratiowas 83.33％). There were no clearing difference between two groups(P＞0.05).There were obvious difference in treat group of the score of bone mineraldensity, the value of estrogen of treatment between before and after 6 months(P＜0.05). Also the same result was resist in control group (P＜0.05),Nodifference between 2 groups (P＞0.05). Through the compared with GuiLuBuShencapsule and XianLingGuBao capsule groups. So we suggested that the GuiLuBuShencapsule has the improvement reaction in the PMOP of remedy effect that wouldbe similar to XianLingGuBao capsule. During the process of observed the 2groups. The results of the experiment show up the GuiLuBuShen capsule can raisethe level of estrogen that can be explained as the function of estrogen-similarand the function for promoting osteoanagensis. It also can be explained therewere obvious effects on medicines of tonifying the kidney to the bone tissue.It would inhibit the development of OP with clinical application. We have toprevent the devolution variation of bone. It would be proved that they wereeffective of remedy medicines. Also proved that modern medical methods oftonifying the kidney could amend the low-lying of the organ immunity system, promte osteo calcin bulk, the function of restraining dessificaation,promoting oste oanagensis, reduce the rate of born mass lose and exalt bonemineral content and bone mineral density to approach the aim of osteoporosistherapy.ConclusionFor the following traits, less of bone mass, micro-structure of bone tissuewill low-lying of primary osteoporosis will he a full size disease of bonethat could cause the brittleness and increase the danger of structure. Theclinical trail was systematic and all-around to refresher on the basic ofreference of modern TCM to remedy the OP. Combined with the resonator of modernTCM on OP. People always think that OP is equal to the name of flacciditysyndrome involving the bone. The specialties of etiology and pathogenesisinclude into blood stasis and illness of deficiency type. The main 3 factorswere consisting of deficiency of kidney, deficiency of spleen and blood stasis.During the factors deficiency of kidney is the major factor. The principlesof remedy is "tonifying the kidney and strengthening, invigorating the spleenand replenishing Qi and promotion blood circulation and dredging collateral".We according to the principle of remedy strategy and the specialties ofthe etiology and pathogenesis in osteoporosis. We draw up the GuiLuBuShencapsule to proceed the experiment of clinical trail in the PMOP through 60patients. The results of this experiment showed the GuiLuBuShen capsule canpromote the bone mass effect. That result could be explained the GuiLuBuShencapsule take on the mechanism to increase bone mass and prove:①It couldimprove the clinical syndrome of patients deficiency of kidney-yang;②It couldimprove and delay the clinical syndrome of patients;③It could improve thequality of the life;④The diplex functions of increase the activity ofosteoblast and restrain deossification;⑤Reduce the function of the boneturnover.⑥Exist the function of estrogen-like. In a word of up words, thetheory about the kidney dominates the bone "of TCM is scientism". Inpresent-day, two kinds of treatment(by promoting osteoanagenesis and byrestrain deossification), some are too expensive, some have serve side effect,some are not so efficient, there are some formulas in Chinese market, mostof these formulas are specially designed to treat "kidney weakness".Kidney take on the important role in the stage of the bone remedy, bonegrowing and all the remedy of bone diseases. The main methods of application that we should tonifying the kidney, match up the method of invigorating thespleen and warming Qi and blood. All these are fit to the recognition in thePMOP of TCM. And it would be a clinical mean and the ideation ground aboutthe remedy of OP. So the GuiluBuShen capsule has to be proved that it iseffectual medicine of OP.
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