A Comparative Study Of Gray Matter Concentration And Functional Connectivity In Schizophrenia Of Different Subtype

OBJECTIVE: The purpose of this study was to explore the differencesin grey matter concentration among normal controls, positive andnegative symptom profile schizophrenia.METHOD: All patients with schizophrenia were diagnosed withDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSM-â…£) of American Psychiatric Association. Structural MRI imageswere obtained from normal controls (n=26), positive (n=23) and negative(n=17) symptom profile schizophrenia. Voxel based morphometry inconjunction with statistical parametric mapping was applied to thestructural magnetic resonance images.RESULT: Compare with the control subjects, the cerebral gray matterconcentration in positive symptom profile schizophrenia had a significantdecrease in the limbic uncus and right fusiform gyrus and celebellum.And the grey matter conconcentration of negtive symptom subtype haddecrease in frontal lobe,temporal lobe,cerebellum, limbic lobe uncus andcuneus. There are difference in grey matter concentration betweennegtive and positive subtype.The change of negtive subtypeschizophrenia is very significant.These results suggested that cerebellumand frontal lobe might be involved in negative symptom. CONCLUSION: Positive and negative symptom profile schizophreniamay have different neurobiological correlates. OBJECTIVE: To explore the differences in resting state functionalconnectivity among normal controls, positive and negative symptomprofile schizophrenia.METHODS: All patients with schizophrenia were diagnosed withDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSM-â…£) of American Psychiatric Association. Functional MRI imageswere obtained from normal controls (n=14), positive (n=14) and negative(n=13) symptom profile schizophrenia in resting state. Functionalconnectivity map for each subject were obtained from each dataset bychoose the left superior temporal gyrus as seed volume of interest (VOI).Independent t test were carried out to explore functional connectivitydiscrepancy between any two of the three groups.RESULT: Compare with the control subjects, functional connectivitywere decreased between left superior temporal gyrus with bilateral orbitalfrontal gyrus, but increased with bilateral cerebellum in negativesymptom profile schizophrenia. Decreased functional connectivity werealso shown between left superior temporal gyrus with bilateral orbitalfrontal gyrus, right inferior occipital gyrus and right cueus. Compare withnegative symptom profile schizophrenia, decreased functional connectivity between left superior temporal lobe with bilateral cerebellumand right inferior occipital gyrus in positive symptom profileschizophrenia. These results suggested that functional connectivitybetween left superior temporal gyrus with orbital frontal gyrus might beparticularly affected in schizophrenia, cerebellum might be involved innegative symptom, and occipital lobe in positive symptom inschizophenia.CONCLUSION: Positive and negative symptom profile schizophreniamay have different neurobiological correlates.