Studies On Intestinal Absorption Mechanism, Pharmacokinetics And Sustained Pellets Of Hawthorn Leaves Flavonoids

D101 macroporus resin was used to isolate and purifying total flavonoids from leaves of Crataegus Pinnatifida Bge., ie. HLF. The in situ rat single-pass intestinal perfusion model, the in vitro rat everted gut sac model and the in situ rat loop model were used to study the intestinal absorption of HLF. Pharmacokinetics study on HLF was also investigated. The results showed that Passive diffusion dominates the absorptive transport behavior of VRH in HLF. The absorption of VRH in HLF is mediated by the efflux transport system, P-gp. VRH in HLF was eliminated quickly in rat plasma, and VRH has linear pharmacokinetics characteristics. The coating solution formulation of HLF sustained pellets was optimized with a three-factor, three-level Box-Behnken design. HLF sustained pellets were prepared by the film coating method of air floating fluid bed. The quality of HLF sustained pellets was also investigated.