The Role Of Monoamine And Relative Receptors In Motion Sickness And The Effect Of Branched-chain Amino Acids And Tyrosine

The mental and physical fatigue induced by sea sickness significantly impaired working performance of marine troops, and it is important to relieve the fatigue after sea sickness. Real-time PCR was employed to detect the changes of 5-HT receptors mRNA expression in rat vestibular nucleus during adaptation process of motion stimulation; Open-field test,Morris water maze and weight-loading-swim test were used to choose the best preparation among the six amino acid preparations for reducing fatigue; HPLC-ED system was used to measure the monoamine in rat brain stems. 5-HT1A,5-HT1B,5-HT1D and 5-HT2A receptors mRNA expression were changed during the adaptation process;NE and E in the brain stem decreased and 5-HT increased after motion stimulation;The low-dose branched-chain amino acids and tyrosine compound recipe has the best effect of increasing physical strength and enhancing space recognition and mental activity after motion stimulation which may functioned through increasing NE and decreasing 5-HT in the brain stem. It is concluded that serotonin receptors may be involved in the adaptation process of sea sickness, and the low-dose BCAA-Tyr compound recipe may help to facilitate the recovery of mental and physical fatigue induced by sea sickness.