1.Regulation Of Prostaglandin Synthesis And Metabolism In Human Placenta And Chorion Mediated By CRH Receptors 2.Regulation Of Prostaglandin Synthesis And 11β-HSD1 Expression In Chorion By Glucocorticoid And Cytokine

Prostaglandins secreted from placenta and fetal membranes during pregnancy play important role in fetal development and initiation of parturition. The levels of prostaglandin are controlled by its synthetase and metabolic enzyme. In this subject, we determined the effects of CRH and its related peptides, glucocorticoids and cytokines on the regulation of cPLA₂, COX-2 and PGDH in placenta and chorion. We found that CRH and its related peptides can differently regulate the expression of prostaglandin synthetase and metabolic enzyme in placenta and chorion by different CRH receptors, which is probably adapted to the individual physiological function of these two kinds of fetus-affiliated organs. We also found that glucocorticoids and proinflamatory cytokine IL-1βcan both upregulate prostaglandin synthesis, and this effect can be accentuated by 11β-HSD1, which is synergistically induced by glucocorticoids and IL-1β. We concluded that prostaglandis in placenta and chorion are regulated by a series of hormones complicatedly and delicately.