| Objects:Senile degenerated heart valvular disease (SDHVD) is the result of degeneration of calcium deposition in the fiber layer of the cardiac valve. In recent years, with the arriving of aging society the incident of SDHVD is increasing year by year domestically and abroad, SDHVD has become the primary reason of cardiac valve replacement in the elderly. This study was based on an epidemiological study on SDHVD 5 years ago. The same people were called back to investigate the epidemiology features of SDHVD, which include analysis of newly diagnosed patients' statistics; relationship between SDHVD and cardiovascular events, new case and correlation risk factor, SDHVD and carotid atherosclerosis.Methods:Firstly a prevalence survey was made in order to make morbidity rates, the risk of cardiovascular events and risk factor clear through questionnaire and echocardiography. Secondly the results were contrasted with that in 2005, and then analysed the characteristics of its changes and new phenomenons during the 5 years by using logistic regression analysis, Cox proportional hazard model and other normal statistical methods.Results:1. There were 739 people in this epidemiological survey, response rate is 90.1%, and morbidity of cardiac valve calcification is 15.6%. Aortic valve calcification took the proportion of 42.6% in all patients; the morbidity in male was higher than female. Mitral valve calcification proportion was 40.0%, female higher than male. In new patients, NCC, RCC(75.0%,37.5%) and PML(58.8%) were the most calcification sites in aortic valve and mitral valve. It was found that most consequences were the same as 5 years ago or other related reports in domestic and overseas.2. SDHVD plays an important role in cardiovascular events, there were 21 new cardiac valve calcification and 7 aggravated patients. In 739 people of this study, there were 7 atrial fibrillation,47 angina,46 heart failure,26 revascularization,49 stroke. By Cox proportional hazard model, the study deemed that smoking, hypertension, stroke, coronary disease and diabetes mellitus were the major risk factor for SDHVD. And the atrial fibrillation is correlative with SDHVD explicitly. Analysed age, valve calcification and new atrial fibrillation by Cox model, it was found that the risk of atrial fibrillation was 3.685 times (P=0.091) greater for SDHVD compared to people without the disease.3. Morbidity of carotid atherosclerosis was 56.7% in the study, increased with age, male higher than female (P<0.01) in amount and degree. The morbidity of valve calcification was 20.2% in the patients who suffer from carotid atherosclerosis in 2005, while the morbidity of carotid atherosclerosis was 62.8% in the patients who suffer from valve calcification in 2005. The result indicated that carotid atherosclerosis could be as predictor for valve calcification.Conclusions:1. There was first five-year longitudinal study in Beijing community.739 people were investigated,41 people were died, and response rate was 90.1%. SDHVD were 115 cases, the morbidity increased from 13.4% to 15.6%, and there were 21 new patients, according with the growth trend of age.2. There were 21 new patients during this five years,7 aggravating patients, the average age was 75.4±4.9 years old. Valve calcification and age increasing were independent risk factors of new atrial fibrillation. Hypertension and hyperlipidemia were independent risk factors for cardiovascular events.3. Carotid atherosclerosis could be as predictor for valve calcification, and Valve calcification may has the same pathogenesis with atherosclerosis.
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