| The incidence rate and the death rate of the lung cancer is very high, most of the patients are on the advanced stage when they are diagnosed. The conventional therapy of lung cancer including the operations,radiotherapy and the chemotherapy has its limit, the effect of the targeted drugs is not certain. The mode of combined therapy is the trend of the treatment of lung cancer. TCM has showed up the superiority of "living with the tumor", but the curative effect are similar in recent years. The acupuncture and moxibustion has the characteristic of innocuousness,ambidirectional dominance and entirety, so it works in the treatment of lung cancer, especially improving symptoms,easing the side effects and raising the curative effect of the radiotherapy and the chemotherapy, and it has little side effect and it charges little. There are many problem in the study and research of the acupuncture and moxibustion, as some of them have no control groups, some have no standard diagnostic criteria,treatment perscription and the evaluation criterion, some have small sample size, and it made the result not confident.This article is about the analysis of curative effect of acupuncture and moxibustion including quality of life,symtoms,side effects of chemotherapy etc in nonsmall-cell lung cance (NSCLC) based on the perspective and control study;and trys to analyse the impact on the of mouse with lung cancer of acupuncture and moxibustion.1 The analysis of curative effect of acupuncture and moxibustion in NSCLC based on the clinical research. OBJECTIVE:Observe the curative effect of acupuncture and moxibustion including quality of life,symtoms,side effects of chemotherapy etc in nonsmall-cell lung cance (NSCLC) based on the perspective and control study.METHODS:From Sep,2008 to Mar,2011,205 patients, with NSCLC in stageⅢ-Ⅳ, were recruited in four hospitals including The 1st affiliated hospital of Guangzhou University of TCM, The 2nd affiliated hospital of Guangzhou University of TCM, Guangzhou Hospital of TCM and Foshan Hospital of TCM.48 cases in group TCM(group T),61 cases in group integrated acupunture with TCM (group A+T),45 cases in group integrated chemotherapy with TCM (group C+T), and 51 cases in group integrated acupunture, chemotherapy with TCM(group A+C+T).Project for group TCM:with combination of syndrome differen-tiation and disease differentiation, Qingjingdesheng tablets and Shenyi capsules were used according to disease differentiation, and different decoctions were determined from four patterns:phlegmatic stagnation due to passive congestion of lungs (FYTY), phlegmatic hygrosis due to spleen asthenia(PXTS), yin-deficiency and phlegmopyrexia(YXTR) and deficiency ofboth qi and yin(QYLX) according to syndrome diffentiation, and the period of treatment was two courses,21days per course. Project for group integrated acupunture with TCM:the treatment of TCM is the same as group TCM. both Lung Shu, Vital Organs, Diaphragm Shu, Gallbladder Shu and Foot Three Li were chosen in the acupunture therapy, the period of treatment was two courses,21days per course. The first 5 days needling and the last 16 days point application. Project for group integrated chemotherapy with TCM:Platinum-based chemotherapy were used besides the treatment of TCM, either NP/GP/DP regimen or Docetaxel/pemetrexed was adopted, and were repeated every 21days, two times. Project for group integrated acupunture, chemotherapy with TCM:the treatment is the same as the last three groups. The primary points was symptoms improvement, survival, quality of life, side effect of chemotherapy improvement, tumor response rate, ECOG.RESULTS:Tumor response rate(CR+PR) were 4.17% of group TCM,4.92% of group A+T,24.44% of group C+T,27.45% of group A+C+T;The disease control rate were 56.25%of group TCM,59.02% of group group A+T,75.56% of group of group C+T,86.27% of group A+C+T. There were statistical significance between group T/ A+T with group C+T/ A+C+T; there were statistical significance between group A+C+T and the other groups in the disease control rate.Symptoms scales changes after treatment of four groups compared:there were statistical significance between group A+C+T and the other groups, there were statistical significance between group C+T and the group T/ A+T.PS scales decrease after treatment of four groups compared:there were statistical significance between group A+C+T and the other groups, there were statistical significance between group C+T and the group T/ A+T.The quality of life changes after treatment of four groups compared: group A+T and group T inproved after the treatment, but group C+T and group A+C+T decreased after the treatment. There were statistical significance between the group A+T and the group T in the emotional condition funtional condition and lung cancer information. And acupunture works for all types of syndrome, especially for the patients who have got phlegmatic hygrosis dueto spleen asthenia(PXTS).Most of the side effect scales worsened after the treatment of group C+T and group A+C+T. Refers to the symtoms like nausea and vomitting,diarrhoea constipation and pruritus, there were statistical significance between group C+T and group A+C+T.WBC and PLT scales changed after treatment of four groups compared: there were statistical significance between group T/ A+T and other two groups, there were statistical significance between group A+C+T and group C+T, there were statistical significance between group A+T and the group T.CEA,CA125,CA199 decreased after the treatment of four groups;CEA,CA199 in group C+T,group A+C+T decreased more than group A+T and group T. Group A+C+T was the lowest, and there were statistical significance between group A+C+T and the other three groups.The heart function,Hepatic function and renal function of the patients has not getten worse after the acupumture therapy. Some patients got subcutaneous hemorrhage,pain after the treatment. The common side effects were erubescence and pruritus. The side effects could be cured, and so the acupumture therapy is safe.CONCLUSI ONS:The treatment integrated acupumture with TCM is better at stabilizing hemogram,improving the quality of life such as emotional condition functional condition and lung cancer imformation than TCM. The treatment integrated chemotherapy,acupumture and TCM is better at improving the sympton,decreasing PS,stabilizing hemogram,increasing the disease control rate,decreasing the side effect of chemotherapy and decreasing CA125 than the treatment integrated chemotherapy and TCM. According to the disease control rate,symptoms improvement tumor markers, acupumture can elevate the effect of chemotherapy. According to the symptoms improvement PS decrease,hemogram,side effect of chemotherapy, acupumture can degrade the toxicity of chemotherapy. And acupunture works for all types of syndrome, especially for the patients who have got phlegmatic hygrosis dueto spleen asthenia(PXTS).According to the disease control rate,symptoms improvement,PS decrease and tumor markers, the treatment integrated chemotherapy,acupumture with TCM is the best way to cure NSCLC. And acupumture is very safe.2 The Experimental Research of acupumture in Treatment of Lewis Lung Cancer(LLC) MiceOBJECTIVE:To analyse the effect of acupuncture and moxibustion on the mice with lung cancer.METHODS:60 C57BL/6 mice were randomly divided into four groups, there were15 mice each group, and four groups as follows:LLC blank (group A), LLC acupumture (group B), LLC chemotherapy(group C) and LLC acupumture and chemotherapy(group D).Step 1:After awaking LLC cells to be frozen by liguid nitrogen, four C57BL/6 mice'right axilla subcutaneous part were inoculated by LLC cells 2.5×105, for establishing transfer of culture LLC mice. The mice were killed after transfer to three generation, and tumor was taken in sterile to make tumor cell suspension which concentration was 5×106/ml. Every mouse'right axilla subcutaneous part was inoculated by 0.2ml tumor cell suspension. On the second day Post inoculation, treatment began. In group B, Both Lung Shu, Foot Three Li were chosen in the acupunture therapy, and every day for 10 days.Group C were administrated intraperitoneal cisplatin by 0. lml/20g every day for 10 days. Group D took the same treatment with group B and group C.RESULTS:After continues treatment for ten days, survival mice number of group A, B, C and D were 15,14,12 and 12 respectively。The death rate of group C and D is higher than group A and B, and group C is higher than group D. Weight of tumor of group A, B, C and D were 3.25±0.26g,2.84±0.41g,2.37±0.47g and 2.03±0.27g respectively;There were statistical significance between group B and group C or D; there were statistical significance between group C and D. Suppress tumor rate of group B,C and D were 12.58%,27.07%,37.41% respectively. Body weight except tumor of group compared:group B is the heavest, but there was no statistical significance between groups.Weight of spleen of group A, B, C and D were 0.20±0.03g,0.27±0.06g, 0.18±0.03g and 0.26±0.05g respectively;Weight of thymus gland of group A, B, C and D were 0.055±0.016g,0.036±0.015g,0.031±0.008g and 0.045±0.012g respectively;there were statistical significance between group A and group B; there were statistical significance between group D and group A or C. Weight of thymus gland compared:group B is the heavies, but there was no statistical significance between groups.Serum TNF-αlevel of group A, B, C and D were 2.00±0.24ng/ml,1.96±0.45ng/ml,2.38±0.28ng/ml,2.31±0.30ng/ml respectively;there were statistical significance between group C/D and group A/B, but there was no statistical significance between group A and B or C and D. Serum IL-6 levels of group A, B, C and D were 126.13±22.85pg/ml,84.48±15.03pg/ml, 110.78±15.25pg/ml,90.95±14.72pg/ml respectively;there were statistical significance between group A and the other groups;there were statistical significance between group B and C.CONCLUSIONS:The treatment of acupumture could suppress tumor growth of LLC mice, which was weaker than chemotherapy, but acupumture integrated with chemotherapy would be better than acupumture only or chemotherapy only.The treatment of acupumture could increase the weight of LLC mice spleen to some extent, and enhance immune function of animal body to some extent.TNF-αand IL-6 is the index that could reflect the lung cancer aggravation therapeutic efficacy and the prognosis, and correlates to the deficient syndrome. Acupumture could decrease serum TNF-αand IL-6 levels significantly, which may be one of important reasons for treating the lung cancer.
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