With Professor Kobayashi Based On Data Mining Application Dried Ginger The Skullcap Coptis People Ginseng To Treat T2dm Drug Law

Objective:By analyzing the clinical data to find the main pulse and symptoms indicated by Ganjiang Huangqin Huanglian Renshen Tang, rules of dosage and the correlation between symptoms and herbs and formula, and further summarize the rules of treating T2DM with this formula and provide evidence for clinical practice, which is considered as guidance for treating T2DM.Subjects:Patients treated by professor Tong Xiaolin in Guang An'men hospital with the modified formula mainly composed of Ganjiang Huangqin Huanglian Renshen (Xiyangshen, Hongs hen, orTaizishen). Referring to the admittance criterion, 368 patients including 744 visits were chosen for this study.Methods:1. Standardization of data:make standards for symptoms, Name of Chinese herbs, and dosage.2. Establish a database:data of 368 patients (744 visits) was put into the software Epidata3.1 by two operators in two different computers, and then exported to Microsoft Office Excel 2007. The data included name, gender, age, treatment duration, BMI, western medication, symptoms, pulse and tongue, fast blood glucose(FBG),2 hours postprandial blood glucose (2h-PBG), glycosylation hemoglobinAlc (HbAlc), blood lipid, islet function, formulas, and dosage. The data didn't include any words, and each variable is coding uniquely. All the data has been checked by missing data imputation, correction of illegal data and data conversion.3. Analysis of data:the data for analysis included symptoms, gender, duration, symptoms, drugs and dosage. By utilizing SPSS16.0, the analysis includes frequency analysis, factor analysis, canonical correlation analysis, cluster analysis and Logistic analysis; to compare the clinical effect before and after treatment with paired t test or Wilcoxon Signed Ranks; analyze correlation with Clement inel2.0.Results:1. Results of summarizing the frequency:core symptoms and pulse indicated by Ganjiang Huanglian Renshen Tang include fatigue, insomnia, blurred vision, dry mouth, nocturia (more than twice), dry stool, sweating, white coating, ecchymosis in the tongue, slightly trembling of the tongue body and deep pulse. 2. Analysis of dosage:average dosage of Ganjiang was 8.21±4.95g (therapeutic dosage ranging from 9 to 15 g); average dosage of Huanglian was 20.84±11.86g (therapeutic dosage ranging from 15 to 30 g); average dosage of Huangqin was 24.97±13.60g (therapeutic dosage ranging from 30 to 45g), average dosage of Xiyangshen was 5.87±2.86g(therapeutic dosage ranging from 6 to 9 g); average dosage of Hongshen was 4.52±3.03 g(therapeutic dosage ranging from 3 to 9g).3. Analysis of correlation:Correlation between principal medicine and FBG:FBG was positively correlated with dosage of Ganjiang, Huanglian and Huangqin, as when FBG was hinger, the dosage of these herbs increased, however the positive correlation between Xiyangshen(Hongshen) is very slight with FBG. Correlation between principal medicine and glycosylation hemoglobinA1c (HbA1c): glycosylation hemoglobinA1c (HbA1c) was positively correlated with Huanglian and Huangiqn, as glycosylation hemoglobinA1c(HbA1c) was higher, both dosage of Huangqin and Huanglian would increase; while Xiyangshen (Hongshen) had a slightly negative correlation with glycosylation hemoglobinA1c(HbA1c); the dosage of Ganjiang is very slight positive correlation with glycosylation hemoglobinA1c(HbA1c).4. Result of cluster analysis:the result of cluster analysis for principal ingredient (Ganjiang, Huagnlian, Huangqin and Xiyangshen), the middle dosage group (Ganjiang 10.96g, Huagnlian 27.09g, Huangqin 32.31g, Xiyangshen 7.12g) occupied the majority of these including 379 visits among 489 (76.10%); the core symptoms and pulse included fatigue, insomnia, blurred vision, dry mouth, nocturia (more than twice), dry stool, sweating, white coating, ecchymosis in the tongue, slightly trembling of the tongue body and deep pulse.5. Analysis of the factors:there were 4 elements for character of disease with duration less than 12 months:qi deficiency, heat, yin deficiency and blood stasis; 3 elements for disease location:stomach, spleen and kidney; there were 4 elements for character of disease with duration between 12 months and 60 months:qi deficiency, xue deficiency, yin deficiency and heat; 4 elements for disease location:spleen, liver, stomach and kidney; there were 4 elements for character of disease with duration between 60 months and 120 months:qi deficiency,yin deficiency, blood stasis and yang deficiency; 3 elements for disease location: spleen, kidney and liver; there were 3 elements for character of disease with duration between 120 months and 180 months:yin deficiency, qi deficiency and blood stasis; 4 elements for disease location:kidney, liver, spleen and stomach. there were 2 elements for character of disease with duration more than 180 months: qi deficiency and yin deficiency; 3 elements for disease location:spleen, kidney and liver. 6. Analysis of correlation:correlation between formula and symptoms indicates that Ganjiang Huangqin Huanglian Renshen Tang had a close correlation with symptoms of fatigue, insomnia, blurred vision, dry mouth, sweating and dizziness. It also proved that the pathogenesis indicated by the formula is spleen deficiency and stomach heat,or combined with yin deficiency.7. Comparison of clinical effect before and after the treatment:in TCM group, for 2 months duration there was obvious difference in FBG (P<0.05); for duration of 3 to 6 months, there was obvious difference in both 2h-PBG and HbAlc(P<0.01, P<0.05). in TCM+WMS group, for duration of 1 month,2 months and 3 to 6 months, there was obvious difference in FBG (P<0.01); for duration of 1 to 2 month, and 3 to 6 months, there was obvious difference in 2h-PBG (P<0.05, P<0.01); for duration of 3 to 6 months, there was obvious difference in HbAlc(P<0.01).8. Result of Logistic regression analysis:relationship between dosage of principal ingredients and clinical effects:as the dosage of Huanglian, Xiyangshen increases, it was more effective.Conclusion:1. Core symptoms and pulse indicated by Ganjiang Huangqin Huanglian Renshen Tang include fat igue, insomnia, blurred vision, dry mouth, nocturia (more than twice), dry stool, sweating, white coating, ecchymosis in the tongue, slightly trembling of the tongue body and deep pulse.2. The pathogenesis indicated by the formula is spleen deficiency and stomach heat, or combined with yin deficiency.3. The commonly used dosage of each ingredient:Ganjiang 9g, Huanglian 30g, Huangqin30g, Xiyangshen6g or Hongshen 6g.4. Ganjiang Huangqin Huanglian Renshen Tang has a positive on effect on lowering Blood Glucose.5. In this formula the effect has positive correlation with dosage of Huanglian, and Xiyangshen.