Osteoarthritis Of The Knee By The Tendons Dialectical And Related Syndrome Factor

Osteoarthritis of knee joint (KOA) is a kind of joint disease with articular cartilage injury.hyperosteogeny chondromalacia patella and inflammatory of ligaments. It often occurs at people over middle age,which badly influences the health and has become the primary reason of people in middle and old age and causing chronic disability.This thesis studied the characteristics of knee osteoarthritis models at different stages by meridian tendons and syndrome elements of TCM.The study will provide reference for clinical therapy for KOA through the research.Objective:Study the clinical pathological mechanism and the characteristics of syndrome elements and meridian tendons to three stage of KOA On the basis of previous studies in order to realize the local meridian syndrome differentiation and whole organs dialectical unity,and provide reference for clinical therapy for KOA.Methods:Method232cases that accorded with operational standard of diagnosis to different clinical staging of KOA through clinical observation. Study on characteristics of TCM Syndromes mainly observe the early, metaphase and late stagse through the syndrome element investigation. And classify the element classification through the cluster analysis mathematical of statistics method which get the common TCM Syndromes to KOA. Using frequency analysis method study KOA patients with knee tendons disease research.Study the relevance of meridian tendons and syndrome elements to KOA.Results:The study on acquired syndrome shows that there have10syndromes which frequency more than5%of a total patients, including the position of disease syndrome factor deficiency syndrome, empirical syndrome (kidney, liver, spleen qi deficiency, blood deficiency, blood stasis, deficiency of Yang, Qi, dampness, phlegm,). A combination of clinical, cluster analysis results into8categories is more reasonable, including four syndromes:kidney deficiency and stagnation of Qi and blood stasis, spleen and kidney deficiency and damp wager, liver and kidney deficiency and blood stasis, liver and kidney deficiency and phlegm stasis block.The KOA patients have different characteristic to every period by visceral syndrome differentiation or meridian tendons. Patients at early stage have kidney deficiency and qi stagnation and blood stasis. Metaphase patients have deficiency of spleen and stomach with pouring of dampness, deficiency of the liver and kidney with blood stasis. The late stagse have deficiency of the liver and kidney with stagnation of phlegm-stasis. In385abnorma knees joint, there have129knees belonging to a single tendon lesions, which Include Yang-ming, Shaoyang; there have207joints belong two compound disease, including Yang sun, Yangming Shaoyang, Yangming three negative, Yangming solar type; three has49joints whicih belong the composite, including the Yangming sun sun sun, Yang Yin type three, type three, Shaoyang sun shade. Pathological changes to early stage of meridian tendons is mainly yang-ming,and metaphase is mainly two meridian tendons, the late stagse is mainly three meridian tendons.Three have no direct correlation to the tendons of syndrome element on meridian tendons.While yang-ming and tai-yang tendons have the distribution of dampness and three yin have the distribution of blood deficiency and qi deficiency.This features Indicate tendons do not enter the Viscera.Conclusion:Kidney deficiency is the pathological basis with the deficiency of spleen and stomach and qi stagnation and blood stasis, phlegm-dampness to KOA through the research. It is a gradual process which have different characteristic at different periods.It realize the unify of the overall zang-fu differentiation and local meridian tendons differentiation.