Effects And Mechanisms Of Renal-Brain-Eye System In Traditional Chinese Medicine To Guaid The Treatment Of Amblyopia

Objective: To explore the essence of renal-brain-eye system in traditional Chinesemedicine, and to find its importance in pathogenesis, therapy processes of amblyopia fromthe documental, animal experimental and theoretical aspects. Providing new thoughts andmethods for clinical research and treatment of amblyopia.Methods:1.modern documental research:74articles published formally on literaturematerials from1984to2011were searched taking the amblyopia as keywords. Types ofsyndromes of amblyopia and the occurrence of traditional Chinese medicine werecalculated to analysis the pathogenesis of amblyopia and regularity of medicine application.2. experimental research: Ultrastructural changes of visual cortex and NMDAR1geneexpression tested by RT-PCR methods of amblyopic cat were observed before and afterapplying ShiMingBao granule through electron microscopy. Function of ShiMingBaogranule on amblyopia were tested. Treatment principles of tonifing kidney and liver,strengthening spleen and qi, nourishing blood on treating amblyopia were discussed.3.Theessence of "kidney-brain-eye system" in traditional Chinese medicine and its role in theprocess of treating amblyopia were explored.Results:1. modern documental research: Reinforcing drugs were found mostcommonly used in treating amblyopia. Medicine of nourishing yin and blood werefollowed. Liver and kidney deficiency, spleen qi deficiency was thought as the mainpathogenesis of amblyopia.2.experimental study: Strabismus caused by visual impairmentwere found being improved in middle dose and high dose groups through morphologicalobservation. The effect sequence were high dose group, middle dose group, low dosegroup, saline group and model group. Differences were not found by horizontal comparison between various parts of the district. NMDAR1expression in17th district and21a district on visual cortex were found decreased in model group. NMDAR1expressionin17th district in middle and high dose groups were found increased compared with modelgroup after the application ShiMingBao granule treatment.3Theoretical research:Humanvisual process includes external light receiving information, analysis, recognition and so on.The congenital essence is the fundamental substance of formation and development ofbrain and eye which is guarantee for the eyes receiving optical information and transfer tothe brain.Brain. Analysis and recognition ability is the key to the formation of visual.kidney, brain and eye has a close relationship in the process of formation of the vision. It iscalled kidney brain eye system. Problems on any link will lead to the occurrence ofamblyopia. Kidney essence deficiency, eyes losing nutrients will lead to amblyopia,brainanalysis, recognition (conscious function) inadequacy may lead to amblyopia.Conclusions:1.Essence of kidney-brain-eye system is that kidney providingmaterial foundation for the brain and eye and normal structure and the function of brainproviding guarantee for accepting lights stimulation of eye.2.Kidney, brain and eye worktogether in amblyopia formation. the pathogenesis of amblyopia are as followed,congenital weakness or postnatal malnutrition cause kidney deficiency which will lead toliver and kidney Yin essence insufficiency. Then essence can't go up and nourish brain.And mental deficiency will cause eyes losing nutrients. So the eye lose the fundamentalresources of visual function and amblyopia forms. In the future research and treatment ofamblyopia, study on brain and treatment principle of nourishing essence should be focusedon which will improve the treatment of amblyopia by applying traditional Chinesemedicine.