Invigorating Kidney Treatment Of Immune-mediated Experimental Study Of Regenerative Anemia In Mice

On the base of ideal effect of tonifying kindey and activating blood in treating aplastic anentia(AA),we go further from gene expression of crythron hematopoiesis, cultuer of heinopietic stemlanestor cell, hematopoictic m icroenviroment and modulators to explore the influence of imnlune factors in pathogenesis of AA and the action mechanism of the method of tonifying kidney and activating blood in treating AA. Tonifying kindey and blood-activating Chinese herbal drugs show the following functions: I Improve the hemograin of immune-induced AA mice, increase the differential count of nucleated cells in bone marrow, prolong the living term. 2.Increase the expression of spectific hematopoiesis gene-GATA-1 in bone marrow cell of immune-induced AA mice and improve the hyperplasia and differentiation of crythron hematopoictic ceIl-CFU-E and BFU-E. 3 .Regulate the disorder T cell subgroup of immune-induced AA mice, suppress the activity of Ts. 4.Suppress the activity of negative modulators such as IL-2, IFN æ…¼? TNF a , reduce the expression of mRNA in IL-2, IFN v ,TNF a Increase the expression the mRNA by promoting the secretion of IL-lO, recover the liematopotcsts. 5. Increase the bone marrow cell compoiient while reduce the fat component, abnormal the caryon and cytometnbramie structure of bone marrow cell and stromal cell, enrich the ribose body , nmitochondrion and rough surfaced endoplasmic reticulum in cytoplasm of several organs amid tissues ,ernbody abvious improvement of heart muscle , liver, immune organs, incretory organs and sexual gland.