Benevolence Stomach Particle Treatment Of Chronic Atrophic Gastritis And Precancerous Lesions Of Clinical And Experimental Research

Review This thesis had reviewed the concept of chronic atrophic gastritis(CAG) precancerous lesion in traditional Chinese medicine. The aetiology, pathology, treatment principal and treatment method were discussed at the same time. Besides of these, this thesis also reviewed the modem research results of the molecular biology and animal models on the CAG precancerous lesion. All these established clinical and experimental foundation of this project.Clinical research: 190 cases of CAG precancerous lesion with Qi deficiency, blood stasis and heat accumulation were divided into two groups randomly . One group accepted the treatment of RENZHUJIANWEI Granual(RZJWG), the other accepted WEIFUCHUN Tablet(WFCT) as control. The whole duration of treatment was 6 months. The results indicated that the total effective rate and curative rate was 91.4% and 69.5% respectively. The clinical effective rate was 93.0%, The effective rate of gastroscope appearance~ atrophy, intestinal metaplasia and dysplasia were 70.1%, 64.1%, 66.4% and 67.9%~ 64.2% of the helicobacter pylori(Hp) cagA became negative after treatment. The score of CEA, PCNA, AgNOR, Bcl-2, P53 and the serological level of nitric oxide(NO) decreased significantly after treatment. All these effects of RZJWG were better than WFCT significantly (PKO.01,0.05).Experimental research: RZJWG could restrain obviously the back mutation of His-mice salmonella typhi TA98, TA 100 induced by several mutagenesis agents (3,4 benzopyrene, DRN, DMBA, MNNG). The micronuleus formation rate of PCES induced by cyclophosphamide (CPA) in mice marrow decreased too. It also could alleviate the auricular tumefaction of mice induced by mixed phlogogen which contained crotonarin and inhibit the activity of ornithine decarboxylase (ODC) induced by crotonarin in the epidermis tissue of mice back. In addition, RZJWG could decrease the number of Balb/3T3 malignant cell transformation focuses induced by 3-MCA and TPA, it also could inhibit the formation of Balb/3T3-4-98t~E~Li~malignant transforming cells clone in the soft agar. There were significant differences between RZJWG and positive controls(P