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Asthenozoospermia Infertility Oxygen Free Radical Mechanism And Research Of Chinese Medicine Treatment

Posted on:2004-10-11Degree:DoctorType:Dissertation
Country:ChinaCandidate:W T YangFull Text:PDF
GTID:1114360095456257Subject:Traditional surgery
Abstract/Summary:PDF Full Text Request
Background:The most part of male infertility is due to astheno-spermia,which is correlated with several factors in the research before.But it is not clear yet.Professor Xufu-song is experienced in treating this disease with TCM,but the mechanism is not known.Although the western medicine had great progress in treating this disease,and the artificial reproductive technology(ART) has improved the chance of fertility due to azoospermatism and severe oligospermia,the natural pregnancy is expected by every couple.TCM is effective in treating this disease,but the mechanism is not clear,and unstandard.Objective:Some research had been undertaken in the relation between oxgen free radical(OFR) and asthenospermia in the recent year.We establish this research to confirm the influence of oxgen free radical and effect of this disease treated by Professor Xufu-song.Method:We first review the documents in treating this disease with TCM and western medicine.More comprehension about the progression of this disease in TCM and western medicine is abtained from the review.It is necessary to carry out an advanced research to this disease from the review.We mainly observed the treatment of 47 cases with this disease in clinic.Computer-asisted sperm analysis(CASA) technology was used to observed the motility change of the sperm. Superoxid dismutase( SOD) in the semen was detected in the laboratory.All the patients were divided into four common syndromes randomizedly according to their symptoms.Results:Several index marked the sperm motility were improved in different level after 1~3 courses of treatment.The cure rate(pregnancy rate)was 10.6%,the significant effective rate was 17%,the total effective rate was 78.7%.The motility of the sperm was significantly improved(P<0.01)from the statistics analysis,and the statistics analysis result suggested that the motility of sperm was correlated with SOD.There were no significant defference of the amount of SOD in the group treated by TCM before and after treatment from the statistics analysis.The possible reason was due to the limited cases.Conclusion:From this research ,we find that the oxgen free radical(OFR) play an important role in the male infertility due to asthenospermia.It is effective treated by Professor Xufu-song,and the experience need advanced research.The pathological process of how the OFR influence the sperm motility need advanced technology to confirm.
Keywords/Search Tags:male infertility due to weak sperm motility, oxgen free radical(OFR), superoxid dismutase( SOD), clinical research
PDF Full Text Request
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