| Chronic myelogenous leukemia(CML),a myeloproliferative disorder arising from malignant transformation of the hematopoietic stem cell, typically follows a chronic, relatively asymptomatic course lasting for months to years. This research is to evaluate the efficacy of moxibustion on immune modulation and change of chromosome of patients with CML. We collected 50 patients with stabe CML. Thirty patients received stimulation of main acupoints Dazhui, Gaohuang(bilateral), Geshu(bilateral) and Pishu (bilateral), the same time second acupoints shenshu(bilateral), Zusanli(bilateral) and Sanyingiao (bilateral) by moxa rolls three times for one week and fifteen minuties each time continuing for three months. We compared the variations of T cell subsets, B cell and nature killer (NK) cells. The results showed relatively decreased proportions of CDS4 T cells subsets with statistical significance (p<0.005). There were increases in the proportions of CD4+ T cells, and B cells relatively but without significant differences. In addition, the chromosome of bone marrow cells showed cytogenetic remission after moxibustion. In conclusions, we found that short term application of moxibustion on special acupoints in CML patients could modulate CD8+T cell subsets. Moxibustionmay have effect of immune modulation and regulation of clinical symptoms in stable CML patients. The modulation of immune system of moxibustion is probably due to its effect on the promotion of the decreased immune mechanism and the depression of overreactive immune response. Therefore moxibustion has the advantages of (1) attenuation of the side effects of chemotherapy (2) increase of the immunity (3) convenience and economical without side effects (4) improvement of many clinical symptoms effectively (5) increase the probability of survival.
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