Headache Rather Transdermal Drug Delivery System Of Pharmaceutical Research

Chuanxiong, as a genuine staple herb of Sichuan, has a function of activating Qi and blood circulation, expelling Wind and alleviating pain. If s clinical using lies mainly in treatment of disharmony of menses, amenorrhea and dysmenorrhea, pain in abdomen, punctuating pain between the chest and hypochondrium, galls caused by tumbling, headache, torpid pain caused by rheumatism. Under the guidance of basic theory of TCM, in combination of modern pharmacology and clinical experimental results, in this research, we chose naphtha of Chuanxiong matched with bormeol as study object, made them transdermal delivery system to improve the suffers' acclimatization, reduce ill effections, enrich clinic dosage forms to serve people better, so as to realize the comprehensive utility of Chuanxiong.Aiming at the above problems, first, content of naphtha and ligustilide was chosen as indexes, single factor experiment as experimental method to compare various extraction technics of naphtha in Chuanxiong, and water-steaming extraction was determined; second, technical condition was optimized, and it is proved that under the best condition, extraction ratio of naphtha can be around 0.45%, while the content of ligustilide can be around 61%.In order to make sure that Tou Tongning transdermal delivery system controllable, stable and effective, research into quality standard of naphtha in Chuanxiong was carried out, and the consequences showed that compounds such as hydroxybenzenes, carbonies, lactones, unsaturations were found in the naphtha, the relative density of which is about 0.9909, refraction ratio about 1.5128, pH value about 4.26, acid number about 27.6, saponification unmber about 223, content of ligustilide about 61%; leaving-sample observation was adopted to study the stability of naphtha in Chuanxiong, and the results signified that the quality and clinical curative effect can be conserved under the circumstance of -20℃, avoiding light, obturation; transdermal velocity was chosen as index, mended Franz diffuse pool adopted to study the outside-body transdermal characteristics of naphtha in Chuanxiong. In order to improve the transdermalpervasion quantity of the drug, several common used permeation promoters were filtered, and the experimental results indicated that the Chuanxiong naphtha itself had good penetrability, whose transdermal velocity can reach about 5^g/cm2 -h. Adding permeation promoters as azone, mixtureof oleic acid and propylene glycol, can increase its penetrate number to about 25^g/cm2 ? h.The pain threshold test and hot plate test were used to work over the matching dosage of Chuanxiong naphtha and borneol, and the outcome showed that the adults can take respectively40mg and 13mg each day. Taking Eudragit Eioo as solvent, the beginning adhibition of the patch and the integrity of the sub as judging indexes, the preparation technics of Tou Tongning patch framework TDD system was pilotly studied with single fractor experiment. We used the method of orthogonal design to optimize the prescription, finding out that the best prescription should be: Eudragit Eioo 6mg/cm2, poiy glycol sebacate 2mg/cm2, cross-linking suceinic acid 0.4mg/cm2, host herb 4.0mg/cm2. Taking transdermal velocity as index, orthogonal design as studying method, we selected the permeation promptor for Tou Tongning Patch, determing the best prescription to be: azone 8%, propylene glycol 24%, oleic acid 8%, and the velocity can reach as fast as around 21/tg/cm2 ? h.Trie estimation of the outside-body quality of Tou Tongning Patch was also investigated, and the instant adhesive is around 4.23 when it was measured with Grounder, the cohesion 31 min with PSTC-7. The outside-body release in accordance with stair equation, the accumulating percentage was respectively 8~10%> 40~509^ 70~80%> 90~100% in l^ 4^ 12> 24 hours. The effective was stable, and the velocity was about 21/ag/cm2 *h. We used white rabbits to menstrate the thrill to skin, finding out it had no thrill to entire skin, and only had gentle thrill to injured skin. Using cavy to carry out this experiment, We found out that it did no harm to skin. The content of ligustilide was 23.32mg/pill in HPLC, and the content of bornel was 9.02mg/pill in GC.Taking average area of positive cell slurry and average non-transparent density as indexes, We menstruated the affection of Tou Tongning Patch on experimental hemi-headache animal...