The Fkbps Structure Neurodegenerative Disease Therapy Pilot Structure-based Discovery And Optimization

32 N-arylsulfonyl α-alkyl L-amino acid esters were synthesized and tested for their neurotrophic activities in vitro. The results showed that compound 3, 5, 10, 12, 13, 14, 15, 20, 21 and 28 exert potent enhancement of the effects of NGF of promoting the survival of PC12 cells; And, compound 12, 13, 15, 20 and 28 display good augmentation on neurite outgrowth in chick dorsal root ganglion (DRG) cultures, of them, compound 12 和 15 exhibit higher activities than GPI-1046.