Pan Kan Browning's Study Of The Efficacy And Pharmacokinetics Of Acute Moderate Normovolemic Hemodilution

The pharmacokinetics and pharmacodynamics of pancuronium in acute moderate isovolemic hemodilution were studied in thirty ASA I patients who were undergoing plastic surger operation.Following pethidine and droperidot premedi-cation, anesthesia was induced with fentanyl(2ug/ kg), thiopentone(4-6mg/kg). To facilitate endo-tracheal intubation, 2% lidocaine was applied topically to the larynx without using any relaxant. Anesthesia was maintained with 60% nitrous oxide in oxygen. Before operation, the venous blood was withdrawn and replacement with 6% dextran(molecular weigh 70,000) and Ringer'slactate solution. The Hct decreased from pre—hemodilution 41% to after hemodilution 28.02%. the hemoglobin from 14. 5% to 10.1l%(P<0.05). Neuromuscular function was monitored by means of accelerometry, T0F stimulation was applied.In the first part of the study, the meuro— muscular blocking potency of pancuronium was determined with cumulative dose-response tech(?)ique. After a bolus injection of pancuronium(ED50), the peak effect(%de-prdssion) and onset of time were recorded, after peak effect was achieved another dose equal to 2ED95 of pancuronium was injected and duration was observed. The results...