Rheumatoid Arthritis Hla-drb Genes And Their Correlation With Autoantibody Study

HLA-DRB allele frequency was tested in 98 RA patients and 166 normal control by PCR method . The result indicated that the allele frequency of DR₄ and DR₅₍₁₁₎ was higher than normal control (P<0.0001), RR was 3.62 and 1.8 respectively. This suggested that DR₄ and DR₅₍₁₁₎ are susceptible genes for RA. While the allele frequency of DR₅₍₁₂₎ and DR₉ was lower in RA patients than normal control, the difference was statistically significant (P<0. 005). This suggested that DR₅₍₁₂₎ and DR₉ are probable protective factors for RA. Clinical data showed that in patients with positive RF, their DR₄ allele frequency was much higher than patients with negative RF (P<0. 05) , while in patients with negative RF, allele frequency of DR₆₍₁₃₎ was higher than those with positive RF. Clinical data analysis also revealed that extra-articular manifestations such as rheumatic vasculitis, Felty's syndrome and organ involvement in northern Chinese patients were relatively rare. But in patients with DR₅₃ allele, symptoms of dry eyes and xerostomia was much less than patients without this allele.Number of joint involvement and severity of joint damage was similiar in DR₄ allele positive and DR₄ allele negative group. Similiar result was observed in DR₅₍₁₁₎ positive and negative group.We studied 5 rheumatic disease multi-case families and tested their DRB allele frequency. The DR₄ allele frequency in RA patients of these families was much higher than...