Aspirin, Clopidogrel, And Combined Inhibition Of Atherosclerosis Hardening Of The Formation And Experimental Study Of The Effects On The Expression Of Mmp-1,

[Background] The beneficial effects of anti-platelet drugs on the primary and second prevention in atherosclerotic disease are verified by lots of clinical trials, and these effects are thought to be the results of their anti-platelet effects. Although activated platelets take part in the development of atherosclerosis, it is not clear whether anti-platelet drugs attenuate the formation and progression of atherosclerosis.[Objective] To evaluate the effects of aspirin, clopidogrel, and their combination on inhibiting the development of aortic atherosclerosis. By investigating the possible mechanism of these anti-platelet drugs on the formation and progression of atherosclerostic plaque, we attempted to provide new clues for the prevention and treatment of atherosclerotic disease.[Methods] Forty-nine male rabbits were divided into five groups. One group of control rabbits (n=9) was fed normal diets. Four other groups fed on high cholesterol diet and injected with 10% Albumin Bovine were received no drug therapy (n=10), aspirin (12mg·kg^-1·d^-1, which correspond to 300mg/d in its clinical use, n=10), clopidogrel (4mg·kg^-1·d^-1 which correspond to 75mg/d in its clinical use, n=10) and the...