Antisense Transforming Growth Factor Beta <sub> 1 </ Sub> Gene Transfection On The Biological Role Of Human Scar Fibroblasts

Cicatricial hyperplasia, like many other fibrosis diseases, is one of the medical problems that have troubled mankind. Cicatricial hyperplasia and cramp following wound healing ruin the beauty of the outer look and even lead to functional disorders. Medical researchers have found no effective cure owing to lack of the understanding of the mechanism of cicatricial genesis and hyperplasia. In recent years, with the development of cytobiology and molecular biology, it has been gradually realized that cicatricial hyperplasia results from the breakdown of the dynamic balance of the interaction between the cell, the extracellular matrix and growth factors. TGF-β₁ plays an important role in the process.TGF-β₁ is one of the important factors involved in cell regulation. It regulates cell growth, proliferation and differentiation through paracrine and autocrine. Research shows that TGF-β₁ plays a role of connector between wounding, inflammation and fibrosis. TGF-β₁ can disrupt the balance between collagen synthesis and degradation and lead to the sedimentation of extracellular matrix. Additionally, it can induce the expression of α- smooth muscle actin in fibroblasts, stimulate synthesis of I-type collagen fibers, and together with other cell factors promote proliferation of fibroblasts. Therefore, the blocking of TGF-β₁ expression is likely a way of controling scar. Applications of anti-sense...