.1. Cardiopulmonary Bypass And Off-pump Coronary Artery Bypass Grafting Coagulation System, Platelet Aggregation And 2 As Well As Aprotinin, Ulinastatin Small Impact On The Coagulation System, Platelet Function And Postoperative Early Myocardial Infarctio

Part oneChanges of coagulation and platelet function in patients undergoing coronary artery sugery with and without cardiopulmonary bypassBackground Recently, Off-pump coronary artery bypass (OPCAB) has been increased. The main advantages of this technique are to avoid the use of cardiopulmonary bypass (CPB), and to improve patients recovery. However, the effects of OPCAB on coagulation and platelet activation have not been reported.Objective This study was designed to evaluate the effects of OPCAB and CABG with CPB on coagulation and platelet function. Method Thirty-four selective patients undergoing coronary artery bypass were randomly assigned to two groups: 16 underwent OPCAB (group OPCAB) and 18 underwent CABG with CPB (group CPB). Blood samples were collected at following time points: Baseline (after anesthesia and before operation), before heparin, the end of operation, 6 hour after operation and 24 hour after operation. Flow Cytometric Analysis was performed to determine platelet activation (P-selectin, CD62p) and the expression of GPIIb-IIIa (CD61). APTT, PT, ACT, fibrinogen and platelet counts were also measured. Postoperative blood...