Hydrochloric Acid Guan-fu A Prime Hemodynamic And Electrophysiological Effects In Acute Ischemia And Chronic Cardiac Dysfunction In Animal Models

Hydrochloric Guanfu base A (GFA) is a new anti-arrhythmic alkaloid with a structure of C20-diterpenoid isolated from the tuber of Aconitum coreanum (Levl.) Raipaics. In pre-clinical studies it was shown to slow conduction velocity in nearly all compartments of the heart in vivo and in vitro and exhibited anti-arrhythmic effects in various experimental arrhythmia animal models. After finished phase I to III clinical trails, GFA has been approved by SFDA to treat some arrhythmias. Most of the participants in the clinical trials, however, were those with mild structure heart disease. This is not the case in emergency arrhythmias in which myocardial ischemia or cardiac insufficiency is complicated. It is necessary to evaluate the effect and safety of GFA in this setting. For this purpose the present study was designed with five parts:Part I: Electrophysiological Effects of Guanfu Base A on Acute Coronary Ischemic ModelsPart II: Hemodynamic Effects of Guanfu Base A on Acute Coronary Ischemic ModelsPart III: Electrophysiological Effects of Guanfu Base A on Chronic Cardiac Insufficiency ModelsPart IV: Hemodynamic Effects of Guanfu Base A on Chronic Cardiac Insufficiency ModelsPart V: The Effect of Guanfu Base A on myocardial cells of Animal...